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Updated: Apr 21, 2026
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Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
Published on: October 15, 2014
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Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis
1Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; University of California Los Angeles, Los Angeles, CA 90095, USA.
Developmental Cell
|November 7, 2014
Abstract:
Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.
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