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Updated: Apr 21, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats
Wei Chen Lu1, Ai Qing Wang2, Xiao Ling Chen3
1Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; KunShan Health Inspection Station, 458 Tongfeng Road, Kunshan 215301, Jiangsu, China.
Abstract:
This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.

