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[Bioinformatic analysis of mouse glucocorticoid-induced tumor necrosis factor receptor-related protein]
Pei Shen1, Zhaoliang Su1, Shengjun Wang1
1Department of Immunology, Institute of Clinical Laboratory Medicine, Jiangsu University, Zhenjiang Key Laboratory of Immunology, Zhenjiang 212013, China.
Objective:
To obtain the amino acid sequence of glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) of mouse with an attempt to predict the structure and function of GITR.
Methods:
The amino acid sequence of GITR was analyzed by bioinformatic methods using the network platforms and some bioinformatic softwares.
Results:
The amino acid sequence of mouse GITR showed a homology of 56% with that of other species, including human. GITR protein was composed of signal peptide, extracellular region, transmembrane domain and intracellular region. The extracellular region of mouse GITR is located at the position of 22-153 amino acid residues. The sequence of mGITR might contain four N-glycosylation sites, four serine phosphorylation sites, one threonine phosphorylation site and one tyrosine phosphorylation site.
Conclusion:
The bioinformatic analysis of mouse GITR could provide a basis for the further expression and functional study of mouse GITR protein.
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