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Updated: Apr 21, 2026

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence FUEL

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Published on: May 23, 2014

Biosensing by luminogens with aggregation-induced emission characteristics.

Ryan T K Kwok¹, Chris W T Leung, Jacky W Y Lam

¹HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-Tech Park, Nanshan, Shenzhen 518057, China.

Chemical Society Reviews

|November 7, 2014

Summary

Aggregation-induced emission (AIE) materials offer a novel approach for highly sensitive fluorescent turn-on biosensors. This review explores AIE mechanisms and designs for advanced biological event detection.

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Area of Science:

Biochemistry
Materials Science
Analytical Chemistry

Background:

Fluorescent biosensors are crucial for in vivo biological studies.
Aggregation-induced emission (AIE) materials are emerging as promising luminogens.
AIE offers enhanced sensitivity for biosensing applications.

Purpose of the Study:

To provide an overview of the AIE phenomenon and its underlying mechanisms.
To summarize recent advancements in the structural design and working principles of AIE biosensors.
To present typical examples of AIE-based biosensors.

Main Methods:

Review of AIE phenomenon and mechanisms.
Analysis of structural designs for AIE biosensors.
Compilation of recent AIE biosensor examples and their applications.

Main Results:

AIE materials enable the development of highly sensitive fluorescent turn-on biosensors.
Understanding AIE mechanisms facilitates rational design of novel biosensing platforms.
Recent studies demonstrate diverse applications of AIE biosensors in biological event monitoring.

Conclusions:

AIE biosensors represent a significant advancement in sensitive biological detection.
The unique properties of AIE materials unlock new possibilities for real-time biological analysis.
Further research into AIE biosensors promises enhanced tools for life science investigations.