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Updated: Apr 21, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
New spleen tyrosine kinase inhibitors: patent applications published during 2011-2013
Atli Thorarensen1, Neelu Kaila
1Inflammation and Immunology Medicinal Chemistry, Pfizer Inc., 200 Cambridgepark Drive, Cambridge, MA 02140, USA.
Abstract:
Spleen tyrosine kinase (SYK) is one of the more advanced small-molecule targets with regard to clinical development for treatment of inflammatory diseases. In this review we continue our analysis of the patent literature covering the time period 2011-2013. The analysis relates to any organization that has filed applications that explicitly discloses SYK as the intended target. In the last 2 years there has been a surge of application with a few new entries in a crowded field with the structural theme of compounds in these applications being a traditional type I ATP competitive inhibitor [ 1 ]. This overview of the SYK patent literature and the learning's of the inhibitors substitution patterns would be an important reading for anyone working in the area of SYK inhibitors.
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