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Updated: Apr 21, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Serotonin transporter polymorphism (5-HTTLPR) in Croatian population.
Jelena Culej1, Mario Štefanović, Ivana Ćelap
1Department of Transfusion and Hemostasis - Clinic for Tumors, Medical School University Hospital Sestre Milosrdnice, Ilica 197, 10000, Zagreb, Croatia, jelena.culej@gmail.com.
The serotonin transporter polymorphism (5-HTTLPR) genotype frequencies in a healthy Croatian population align with previous Caucasian studies. This research contributes to understanding genetic variations in psychiatric research.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The serotonin transporter polymorphism (5-HTTLPR) is extensively studied in psychiatric research.
- 5-HTTLPR influences serotonin transporter function, impacting neural activity and homeostasis.
- Previous studies have linked 5-HTTLPR to depression, anxiety, and psychotherapy response, but replication has been inconsistent.
Purpose of the Study:
- To determine genotype frequencies of 5-HTTLPR in a healthy Croatian population.
- To compare these frequencies with existing data from other Caucasian populations.
- To investigate potential sources of error in genetic association studies.
Main Methods:
- Genotyping of the 5-HTTLPR polymorphism.
- Analysis of genotype and allele frequencies.
- Comparison with published data from other Caucasian cohorts.
- Assessment of Hardy-Weinberg equilibrium.
Main Results:
- Genotype distribution: LL (38%), LS (45%), SS (17%).
- Allele frequencies: L (61%), S (39%).
- Results were consistent with the Hardy-Weinberg equilibrium and previous studies on Caucasian populations.
Conclusions:
- The genotype distribution in the healthy Croatian population is similar to other Caucasian populations.
- Variations in study inclusion criteria and population selection may contribute to inconsistencies in previous 5-HTTLPR research.
- Potential for selection bias and population stratification highlights the complexity of psychiatric genetic association studies.
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