Polyp Clearance via Operative and Endoscopic Polypectomy in Patients With Peutz-Jeghers Syndrome After Multiple Small...

Area of Science:

• Gastroenterology
• Genetics
• Surgical Oncology

Background:

• Peutz-Jeghers syndrome (PJS) is an inherited disorder characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyps.
• PJS polyps frequently lead to complications such as intussusception and intestinal hemorrhage, necessitating frequent surgical interventions.
• Patients with PJS often undergo multiple laparotomies and intestinal resections throughout their lives.

Purpose of the Study:

• To report a case of Peutz-Jeghers syndrome managed with a combined operative and endoscopic polypectomy technique.
• To evaluate the efficacy of this combined approach in managing extensive polyposis in a PJS patient.
• To highlight the benefits of this technique in reducing the need for frequent laparotomies and associated complications.

Main Methods:

• A 40-year-old male patient with a 20-year history of Peutz-Jeghers syndrome and prior intestinal resections was treated.
• A combined operative and endoscopic polypectomy strategy was employed to remove gastrointestinal polyps.
• Over 100 polyps were successfully removed using this integrated approach.

Main Results:

• The combined operative and endoscopic polypectomy successfully removed more than 100 hamartomatous polyps.
• This technique resulted in a "clean" small intestine, significantly reducing the polyp burden.
• The intervention aimed to provide a longer interval between future surgical procedures.

Conclusions:

• Combined operative and endoscopic polypectomy is an effective strategy for managing extensive polyposis in Peutz-Jeghers syndrome.
• This approach can significantly reduce the frequency of major abdominal surgeries and their associated morbidity.
• The technique offers a promising method for improving long-term patient outcomes in Peutz-Jeghers syndrome.