Related Experiment Video
Updated: Apr 21, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
Published on: May 23, 2025
Leptomeningeal carcinomatosis associated with papillary renal cell carcinoma
Abhishek Chilkulwar1, Ramya Pottimutyapu2, Fawng Wu2
1Department of Haematology and Oncology, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
Abstract:
Leptomeningeal carcinomatosis (LMC), or neoplastic meningitis, occurs in about 5-20% of patients with metastatic cancer, depending on the type of the primary malignancy and kind of treatment received. The association of LMC with renal cell carcinoma (RCC) is a rare entity, and only two cases of papillary renal cell cancer with leptomeningeal metastasis have been reported. Leptomeningeal spread usually confers a poor prognosis despite the use of modern treatment strategies as compared to patients with extracranial metastases. We report a case of papillary RCC, a less common type of RCC presenting with LMC.

