Related Experiment Video

Updated: Apr 21, 2026

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

14.2K

The possible efficacy of artichoke in fluconazole related hepatotoxicity

Hüseyin Kurt1, Omer Toprak1, Erdoğan Bülbül2

  • 1Department of Internal Medicine, Balıkesir University School of Medicine, 10020 Balıkesir, Turkey.

Case Reports in Hepatology
|November 7, 2014
PubMed

Insights

Fluconazole-induced liver injury is rare but serious. This case highlights a patient with multiple sclerosis who recovered from drug-induced hepatotoxicity using artichoke leaf extract, demonstrating its potential therapeutic benefits.

Area of Science:

  • Hepatology
  • Pharmacology
  • Integrative Medicine

Background:

  • Fluconazole-related hepatotoxicity (FRH) is a rare but potentially severe adverse drug reaction.
  • While often associated with immunocompromised states (e.g., AIDS, bone marrow transplant), FRH can occur in other patient populations.
  • Hepatotoxicity presents with elevated liver enzymes and jaundice, requiring prompt management.

Purpose of the Study:

  • To report a case of fluconazole-induced hepatotoxicity in a patient with multiple sclerosis.
  • To investigate the potential therapeutic role of artichoke leaf extract in managing drug-induced liver injury.
  • To highlight the importance of considering alternative treatments for drug-induced liver injury.

Main Methods:

  • A patient with multiple sclerosis developed hepatotoxicity after a single dose of fluconazole, following methylprednisolone treatment.
  • Liver function tests, including ALT, AST, and bilirubin, were monitored.
  • The patient was treated with artichoke leaf extract (30 mg, three times daily).

Main Results:

  • The patient presented with significantly elevated ALT (1200 U/L) and AST (800 U/L) levels, and high bilirubin (37 mg/dL).
  • Following treatment with artichoke leaf extract, bilirubin levels declined significantly within the first week.
  • All liver function tests normalized within two months.

Conclusions:

  • Artichoke leaf extract may possess anticholestatic and antioxidant properties beneficial in managing fluconazole-induced hepatotoxicity.
  • This case suggests that artichoke extract could be a valuable complementary therapy for drug-induced liver injury.
  • Further research is warranted to confirm the efficacy and safety of artichoke extract in treating drug-induced liver injury.

More Related Videos

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

3.1K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.9K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
370
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
367
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
393
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
266
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
647
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
791