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Updated: Apr 21, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Role of insulin resistance in uric acid nephrolithiasis
Hanhan Li1, Dane E Klett1, Raymond Littleton1
1Hanhan Li, Dane E Klett, Raymond Littleton, Jack S Elder, Jesse D Sammon, VUI Center for Outcomes Research Analytics and Evaluation, Henry Ford Health System, Detroit, MI 48202, United States.
Abstract:
Metabolic syndrome has been implicated in the pathogenesis of uric acid stones. Although not completely understood, its role is supported by many studies demonstrating increased prevalence of uric acid stones in patients with metabolic syndrome and in particular insulin resistance, a major component of metabolic syndrome. This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation, in particular. We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis.
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