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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Apr 21, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

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Prostate epithelial stem and progenitor cells.

Oh-Joon Kwon1, Li Xin2

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine USA.

American Journal of Clinical and Experimental Urology
|November 7, 2014
PubMed
Summary
This summary is machine-generated.

Prostate stem cells drive tissue regeneration and prostate cancer. Understanding these stem cells and their environment is key for preventing and treating prostate cancer.

Keywords:
Prostate stem cellslineage hierarchylineage tracingnicheplasticityprostate regeneration

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Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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Related Experiment Videos

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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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Area of Science:

  • Urology
  • Cell Biology
  • Cancer Research

Background:

  • Prostate epithelia exhibit significant regenerative potential, as shown by androgen ablation and replacement experiments.
  • This regeneration implies the existence of prostate stem/progenitor cells, which are crucial for tissue homeostasis.
  • These stem cells are implicated as the cells of origin for prostate cancer.

Purpose of the Study:

  • To review methodologies for studying prostate stem cell activity.
  • To summarize advancements in identifying prostate stem/progenitor cells and their niches over the past two decades.
  • To discuss unresolved questions in prostate stem cell research.

Main Methods:

  • Review of in vitro techniques for prostate stem cell research.
  • Analysis of in vivo models for studying prostate stem cell function.
  • Synthesis of findings from two decades of prostate stem cell studies.

Main Results:

  • Established in vitro and in vivo approaches are available for prostate stem cell research.
  • Significant progress has been made in characterizing prostate stem/progenitor cells and their niches.
  • The role of these cells in prostate cancer development is increasingly understood.

Conclusions:

  • Characterizing prostate stem/progenitor cells and their niches is vital for understanding prostate cancer.
  • Further research is needed to address outstanding questions regarding prostate stem cell biology.
  • This knowledge holds potential for improving prostate cancer prevention, diagnosis, and prognosis.