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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Cytotoxic sesterterpenoids isolated from the marine sponge Scalarispongia sp
Yeon-Ju Lee1, Jeong-Woo Lee2, Dong-Geun Lee3
1Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea. yjlee@kiost.ac.
International Journal of Molecular Sciences
|November 7, 2014
Abstract:
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 μM) against six human cancer cell lines.

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