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Related Experiment Video

Updated: Apr 21, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Neurocognitive changes after lung transplantation.

Patrick J Smith1, Sara Rivelli, Alexa Waters

  • 11 Department of Psychiatry and Behavioral Sciences.

Annals of the American Thoracic Society
|November 7, 2014
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Summary
This summary is machine-generated.

Neurocognitive impairments are common in lung transplant recipients, with over half showing deficits post-surgery. Delirium during hospitalization is linked to worse long-term cognitive function in non-cystic fibrosis patients.

Keywords:
deliriumlung transplantationneurocognitive performance

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Area of Science:

  • Medical research
  • Transplantation science
  • Neuroscience

Background:

  • Neurocognitive impairments impact quality of life and treatment adherence.
  • Prevalence of neurocognitive deficits post-lung transplant is not well-established.

Purpose of the Study:

  • To determine the frequency of neurocognitive impairment in lung transplant recipients.
  • To identify perioperative factors influencing post-transplant neurocognitive function.

Main Methods:

  • Serial neurocognitive assessments using RBANS, Trail Making Test, and MoCA.
  • Evaluated 47 lung transplant recipients pre-transplant, at discharge, and 3 months post-discharge.
  • Assessed in-hospital delirium using the Confusion Assessment Method.

Main Results:

  • 45% of recipients had pre-existing neurocognitive impairment (MoCA < 26).
  • Post-transplant impairment rose to 57%, persisting in 57% at 3 months.
  • Delirium during hospitalization correlated with poorer follow-up cognitive performance (P = 0.006).

Conclusions:

  • Neurocognitive impairments are highly prevalent in lung transplant candidates and recipients.
  • Cognitive function may worsen post-transplant in some individuals.
  • In-hospital delirium is a significant risk factor for worse neurocognitive outcomes in non-cystic fibrosis lung transplant patients.