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Receptor-targeted drug delivery: current perspective and challenges.
Imran Vhora1, Sushilkumar Patil, Priyanka Bhatt
1Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara-390001, Gujarat, India.
Therapeutic Delivery
|November 7, 2014
Summary
Developing targeted drug delivery systems faces challenges in understanding receptor expression, ligand choice, and nanocarrier limitations. Overcoming these hurdles is key for efficient clinical applications of receptor-targeted therapies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Receptor-targeted drug delivery aims for active targeting but faces limited clinical translation.
- Challenges exist in understanding receptor expression, accessibility, and identifying novel targets.
Purpose of the Study:
- To review the multifaceted challenges in developing receptor-targeted drug delivery systems.
- To explore strategies for overcoming these hurdles for improved therapeutic efficacy.
Main Methods:
- Literature review of current research on receptor-targeted drug delivery.
- Analysis of challenges related to receptor identification, ligand conjugation, and nanocarrier design.
Main Results:
- Significant hurdles include insufficient knowledge of differential receptor expression and accessibility.
- Ligand-related issues encompass selection, conjugation chemistry, and drug release mechanisms.
- Nanocarrier systems, despite advantages, present their own set of development challenges.
Conclusions:
- Addressing receptor, ligand, and nanocarrier challenges is crucial for advancing targeted drug delivery.
- Developing efficient and clinically viable targeted drug delivery systems requires overcoming these identified obstacles.
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