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Area of Science:

  • Molecular medicine
  • Biotechnology
  • Drug delivery systems

Background:

  • Intracellular drug delivery faces challenges due to cell membrane barriers.
  • Peptides, proteins, and nucleic acids require specialized carriers for intracellular access.

Purpose of the Study:

  • To review the design of precise, sequence-defined delivery carriers for intracellular therapeutics.
  • To highlight the need for multifunctional and reproducibly manufactured carrier systems.

Main Methods:

  • Review of sequence-defined carriers, including solid-phase synthesized peptides and nonpeptidic oligomers.
  • Examination of nucleotide-based carriers such as aptamers and origami nanoboxes.

Main Results:

  • Carrier systems must be multifunctional to overcome extra- and intracellular barriers.
  • Precise and reproducible manufacturing is crucial for pharmaceutical applications.

Conclusions:

  • Targeted delivery carriers offer a promising strategy for molecular medicine.
  • Advanced carriers like aptamers and nanoboxes are key to enabling intracellular drug delivery.