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Related Concept Videos

Diffusion01:21

Diffusion

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
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Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

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Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
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Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
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Exhibiting cross-diffusion-induced patterns for reaction-diffusion systems on evolving domains and surfaces.

A Madzvamuse1, R Barreira2

  • 1School of Mathematical and Physical Sciences, Department of Mathematics, University of Sussex, Pevensey III, 5C15, Falmer, Brigton, BN1 9QH, England, UK.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|November 7, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a novel finite element method for reaction-diffusion systems with cross-diffusion on evolving surfaces, revealing new pattern formation possibilities. The flexible methodology accurately models complex domain and surface evolution dynamics.

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Area of Science:

  • Computational Mathematics
  • Mathematical Modeling
  • Chemical Kinetics

Background:

  • Reaction-diffusion systems are fundamental to modeling pattern formation in biological and chemical systems.
  • Cross-diffusion introduces complex dynamics not captured by classical models.
  • Simulating these systems on evolving domains presents significant computational challenges.

Purpose of the Study:

  • To present the first application of the finite element method (FEM) for reaction-diffusion systems with cross-diffusion on continuously evolving domains and surfaces.
  • To investigate pattern formation arising from these systems under cross-diffusion effects.
  • To demonstrate the robustness and versatility of the proposed FEM approach.

Main Methods:

  • Development of a FEM framework for reaction-diffusion systems incorporating linear cross-diffusion.
  • Approximation of evolving domains and surfaces using triangulations.
  • Definition of a finite element space for functions on these triangulated domains/surfaces.
  • Numerical computation of patterns using parameter values specific to the cross-diffusion space.

Main Results:

  • Successful application of FEM to solve reaction-diffusion systems with cross-diffusion on evolving domains/surfaces.
  • Generation of novel patterns driven by cross-diffusion effects, distinct from classical reaction-diffusion patterns.
  • Demonstration of the methodology's ability to handle complex domain/surface evolution, including isotropic, anisotropic, and concentration-driven growth.

Conclusions:

  • The presented FEM is a robust, flexible, and versatile tool for analyzing reaction-diffusion systems with cross-diffusion on dynamic geometries.
  • Cross-diffusion plays a crucial role in pattern formation, enabling phenomena not observed in standard models.
  • The methodology provides a powerful framework for studying complex spatio-temporal dynamics in evolving systems.