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C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study
H Schlenz1, T Intemann1, M Wolters1
1Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
International Journal of Obesity (2005)
|November 8, 2014
Summary
This study establishes reference values for C-reactive protein (CRP) in young European children. Findings show CRP levels vary by age and sex, providing crucial data for pediatric health assessments.
Area of Science:
- Pediatric Health
- Biomarkers
- Inflammation Research
Background:
- C-reactive protein (CRP) is a key indicator of inflammation, vital for diagnosing and monitoring various diseases.
- Limited data exists on serum CRP level distribution in young European children, necessitating the establishment of reference values.
Purpose of the Study:
- To determine population-based reference values for high-sensitivity C-reactive protein (hs-CRP) concentrations in European children aged 2.0-10.9 years.
- To address the scarcity of data on CRP levels in this demographic for improved clinical evaluation.
Main Methods:
- Analysis of hs-CRP concentrations in 9,855 children aged 2.0-10.9 years.
- Data sourced from the European IDEFICS study (2007-2010).
- Stratification of reference values by age and sex.
Main Results:
- CRP values were below the detection limit (0.2 mg/l) in 44.1% of children.
- A slight negative trend in median CRP concentrations was observed with increasing age in both boys and girls.
- Serum CRP levels were marginally higher in girls compared to boys across all age groups.
Conclusions:
- Established population-based CRP reference values can aid pediatricians in clinical practice.
- Elevated CRP levels in children may warrant further investigation or treatment.
- These reference values serve as a foundation for future research on disease risk assessment associated with CRP levels in children.
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