Related Experiment Video

Updated: Apr 21, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Role of farnesoid X receptor in inflammation and resolution

Firdose Begum Shaik1, Durbaka V R Prasad, Venkata Ramireddy Narala

  • 1Department of Zoology, Yogi Vemana University, Kadapa, 516 003, AP, India.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|November 8, 2014
PubMed
Abstract

Insights

Farnesoid X receptor (FXR) is a key regulator of metabolism and inflammation. This review highlights FXR's anti-inflammatory and anti-fibrotic roles in chronic diseases, identifying it as a potential therapeutic target.

Area of Science:

  • Nuclear hormone receptor superfamily
  • Ligand-dependent transcription factor

Background:

  • FXR regulates bile acid, lipid, and carbohydrate metabolism.
  • FXR also plays a significant role in inflammatory responses.
  • Its anti-inflammatory and anti-fibrotic effects in chronic diseases require further documentation.

Purpose of the Study:

  • Review developments in farnesoid X receptor (FXR) biology.
  • Discuss FXR ligands and functions, focusing on anti-inflammatory and anti-fibrotic roles.
  • Explore FXR's potential in treating chronic inflammatory diseases.

Main Methods:

  • Literature survey conducted using PubMed database.
  • Focused on gathering information regarding FXR and its role in inflammation.

Main Results:

  • FXR is highly expressed in the liver, intestine, kidney, and adrenals.
  • Natural ligands include primary bile acids; synthetic agonists like GW4064 exist.
  • FXR is a key metabolic regulator with potential as a drug target.

Conclusions:

  • FXR demonstrates significant anti-inflammatory and anti-fibrotic properties.
  • Its role in chronic inflammatory diseases is a promising area for therapeutic development.
  • FXR represents a potential drug target for metabolic syndromes involving inflammation.

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