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Kidney function in severely obese adolescents undergoing bariatric surgery
Nianzhou Xiao1, Todd M Jenkins, Edward Nehus
1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Obesity (Silver Spring, Md.)
|November 8, 2014
Summary
Many severely obese adolescents undergoing weight loss surgery show early signs of kidney dysfunction. Factors like female gender, high BMI, and insulin resistance are linked to kidney issues in this population.
Area of Science:
- Pediatric Nephrology
- Obesity Medicine
- Bariatric Surgery Outcomes
Background:
- Severely obese adolescents represent a growing population undergoing bariatric surgery.
- Kidney function in this demographic prior to significant weight loss is not well-characterized.
- Early detection of kidney dysfunction is crucial for long-term health management.
Purpose of the Study:
- To assess kidney function using objective measures in severely obese adolescents before weight loss surgery.
- To identify factors associated with kidney dysfunction in this cohort.
Main Methods:
- Analysis of cross-sectional data from 242 adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study.
- Kidney status evaluated via urine albumin-to-creatinine ratio (microalbuminuria) and serum cystatin C-based estimated glomerular filtration rate (eGFR).
Main Results:
- 14% of participants had microalbuminuria, and 3% had macroalbuminuria.
- 3% had an eGFR < 60 ml/min/1.73 m²; 7.1% had an eGFR > 150 ml/min/1.73 m².
- Female gender and elevated ferritin levels correlated with albuminuria. Higher BMI and insulin resistance (HOMA-IR) were associated with lower eGFR.
Conclusions:
- A notable proportion of severely obese adolescents exhibit early kidney dysfunction before bariatric surgery.
- Further longitudinal research is required to determine the reversibility of these kidney abnormalities after weight loss.
- These findings highlight the importance of monitoring kidney health in adolescents with severe obesity.
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