Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

880
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
880
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

608
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
608
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

786
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
786
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.8K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.8K
Tissue Transplantation01:24

Tissue Transplantation

1.3K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.

Circulation·2018
Same author

Publisher Correction: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

Nature reviews. Nephrology·2018
Same author

Staging systems use for risk stratification of systemic amyloidosis in the era of high-sensitivity troponin T assay.

Blood·2018
Same author

Overall survival of transplant eligible patients with newly diagnosed multiple myeloma: comparative effectiveness analysis of modern induction regimens on outcome.

Blood cancer journal·2018
Same author

Autologous Stem Cell Transplant for IgM-Associated Amyloid Light-Chain Amyloidosis.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2018
Same author

Peripheral blood biomarkers of early immune reconstitution in newly diagnosed multiple myeloma.

American journal of hematology·2018

Related Experiment Video

Updated: Apr 21, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.6K

Multiple myeloma after kidney transplantation.

Sami Safadi1, Angela Dispenzieri, Hatem Amer

  • 1Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Clinical Transplantation
|November 8, 2014
PubMed
Summary

Multiple myeloma (MM) after kidney transplantation (KTx) is rare but can occur. Patients often have a history of monoclonal gammopathy of undetermined significance (MGUS) and may experience renal complications, though survival is comparable to MM without KTx.

Keywords:
end-stage renal diseasekidney transplantationmonoclonal gammopathymultiple myelomaparaproteinemiarenal allograft dysfunction

More Related Videos

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K
Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

22.0K

Related Experiment Videos

Last Updated: Apr 21, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.6K
Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K
Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

22.0K

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • Multiple myeloma (MM) developing post-kidney transplantation (KTx) is infrequently documented.
  • Outcomes for MM patients who have undergone KTx require further investigation.

Purpose of the Study:

  • To evaluate the characteristics and outcomes of patients who develop MM after KTx.
  • To assess the impact of MM on kidney allograft survival and overall patient prognosis.

Main Methods:

  • Retrospective analysis of patients diagnosed with MM after KTx between 2001 and 2012.
  • Exclusion of patients with pre-existing MM or treatment for monoclonal gammopathy of renal significance (MGRS) before KTx.

Main Results:

  • Seven patients developed MM post-KTx, with diverse underlying causes for end-stage renal disease (ESRD).
  • Four patients experienced kidney allograft failure due to monoclonal protein-related renal disease.
  • Median survival post-MM diagnosis was 80 months; treatments included chemotherapy and autologous stem cell transplantation (ASCT).

Conclusions:

  • MM following KTx is a rare occurrence, frequently preceded by monoclonal gammopathy of undetermined significance (MGUS).
  • Significant renal involvement is noted in these patients.
  • Survival outcomes for MM post-KTx appear comparable to those without a transplant history, warranting further research into optimal therapeutic strategies.