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Updated: Apr 21, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

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[The morphofunctional prerequisites for the development of exudative otitis media in the children presenting with

R I Pleshko, A B Starokha, Nn V Shcherbik

    Vestnik Otorinolaringologii
    |November 8, 2014
    PubMed

    Insights

    Chronic adenoiditis in children involves impaired nasolaryngeal immunity. Structural changes in pharyngeal tonsils predict complications and immune disturbances in pediatric chronic adenoiditis.

    Area of Science:

    • Pediatric immunology
    • Otorhinolaryngology
    • Histopathology

    Context:

    • Chronic adenoiditis (CA) affects the nasolaryngeal barrier.
    • Understanding immune dysfunction in pediatric CA is crucial.
    • Pharyngeal tonsils play a key role in local immunity.

    Purpose:

    • To investigate structural and functional mechanisms of nasolaryngeal barrier disturbances in children with chronic adenoiditis.
    • To analyze histological and immunohistochemical markers in pharyngeal tonsils of children with complicated and uncomplicated CA.
    • To correlate pharyngeal tonsil characteristics with immune reactivity and complication predictors.

    Summary:

    • Complicated chronic adenoiditis shows reduced markers of active inflammation and smaller lymphoid follicles with fewer macrophages, indicating impaired immune reactivity.
    • Uncomplicated chronic adenoiditis exhibits increased B-lymphocytes (CD20) and CD69-positive cells, suggesting heightened immune activity.
    • Both forms show similar IgA-producing lymphocytes but reduced T-helpers (CD4), indicating a compromised immune response in pediatric chronic adenoiditis.

    Impact:

    • Identified structural characteristics of pharyngeal tonsils can predict immune disturbances and complications in chronic adenoiditis.
    • Findings contribute to understanding the pathogenesis of chronic adenoiditis and its sequelae.
    • Provides potential biomarkers for assessing disease severity and predicting outcomes in pediatric patients.

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