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A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization
Benjamin D Fairbanks1, Michael P Schwartz1, Alexandra E Halevi1
1Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Advanced Materials (Deerfield Beach, Fla.)
|November 8, 2014
Abstract
None:
Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.
