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Genitofemoral neuralgia: a review
Alper Cesmebasi1, Abhishek Yadav, Jerzy Gielecki
1Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota; Department of Anatomical Sciences, School of Medicine, St. George's University, Grenada, West Indies.
Summary
Genitofemoral neuralgia causes debilitating neuropathic groin pain along the genitofemoral nerve. This review covers its anatomy, diagnosis, and treatments, including emerging options like radiofrequency ablation.
Area of Science:
- Neurology
- Pain Medicine
- Surgical Anatomy
Background:
- Genitofemoral neuralgia is a neuropathic pain condition characterized by chronic groin pain.
- Symptoms include burning sensations and paresthesias radiating from the lower abdomen to the medial thigh.
- It is often linked to iatrogenic nerve injury from inguinal or femoral hernia repair.
Purpose of the Study:
- To review the anatomy of the genitofemoral nerve.
- To discuss diagnostic challenges and techniques for genitofemoral neuralgia.
- To outline current and emerging treatment options for this condition.
Main Methods:
- Review of anatomical distribution of the genitofemoral nerve.
- Analysis of diagnostic criteria and differential diagnosis strategies.
- Compilation of treatment modalities including medical, interventional, and surgical approaches.
Main Results:
- Genitofemoral neuralgia presents with distinct symptoms but can be confused with ilioinguinal/iliohypogastric nerve issues.
- Differential nerve blocks are crucial for accurate diagnosis.
- Various treatments exist, from conservative management to advanced procedures.
Conclusions:
- Accurate diagnosis of genitofemoral neuralgia is essential for effective pain management.
- A multimodal treatment approach is often necessary.
- Emerging techniques like ultrasound-guided radiofrequency and cryoablation offer new therapeutic avenues.

