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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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DNA damage in children with obstructive adenotonsillar hypertrophy

Ozgur Yoruk1, Hakan Alp, Sancak Yuksel

  • 1From the *Medical Faculty, Department of Otolaryngology and Head and Neck Surgery, Ataturk University, Erzurum, Turkey; †Medical Faculty, Department of Biochemistry, Yuzuncu Yıl University, Van, Turkey; ‡Department of Otorhinolaryngology-Head & Neck Surgery, University of Texas Medical School at Houston, Houston, Texas; and §Medical Faculty, Department of Biochemistry, Ataturk University, Erzurum, Turkey.

The Journal of Craniofacial Surgery
|November 8, 2014
PubMed
Summary

Children with obstructive adenotonsillar hypertrophy show increased oxidative DNA damage, indicated by higher levels of 8-hydroxy 2-deoxyguanosine (8-OhdG) and malondialdehyde (MDA). This suggests a link between airway obstruction and cellular damage in pediatric patients.

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