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Published on: August 2, 2017
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Millisecond timescale synchrony among hippocampal neurons
Kamran Diba1, Asohan Amarasingham2, Kenji Mizuseki3
1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, New Jersey 07102, diba@uwm.edu.
Summary
Cortical inhibitory neurons synchronize at millisecond timescales, influencing neuronal activity and timing. This synchrony, driven by inhibition, impacts downstream pyramidal cells in the hippocampus.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Inhibitory neurons are crucial for temporal dynamics in cortical circuits.
- Coherent interneuron activation across timescales is essential for neuronal function.
Purpose of the Study:
- To investigate how local hippocampal circuitry facilitates millisecond-timescale interneuron synchrony.
- To identify the functional implications of this rapid synchrony in neuronal populations.
Main Methods:
- Large-scale recordings from CA1 and CA3 hippocampal regions in freely moving rats.
- Resampled cross-correlation analyses applied to neuronal population activity.
- Identification of effective neuronal couplings and synchrony on millisecond timescales.
Main Results:
- Prominent millisecond timescale synchrony observed between hippocampal cell pairs.
- Synchrony was independent of network state, excitatory input, and gamma oscillations.
- Synchrony occurred between different interneuronal types, suggesting inhibition as a key driver.
Conclusions:
- Inhibition alone can synchronize interneurons at millisecond timescales.
- This synchrony can enhance inhibition and rebound spiking in target neurons.
- Millisecond interneuron synchrony may shape timing in pyramidal populations within and downstream of hippocampal circuits.
