Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guided roll flap in combination with static computer-assisted implant surgery: A technique report.

Clinical advances in periodontics·2026
Same author

Region- and Compartment-Specific Elevation of Bone Mass in Mice Following Tsc1 Deletion in 8-kb Dmp1-Cre-Expressing Cells.

Calcified tissue international·2026
Same author

Stem cell-based therapy for bone regeneration: Periodontists' and oral maxillofacial surgeons' considerations.

Journal of the American Dental Association (1939)·2026
Same author

Comparative analysis of outcomes of radiofrequency ablation for incompetent great saphenous varicose vein using F-care (monopolar) and ClosureFast (segmental) systems and a method to improve outcomes in the monopolar system.

Phlebology·2026
Same author

Consensus Report of Group 4 of the 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: Conventional Dentures, Implant Overdentures and Implant-Supported Fixed Dental Prostheses.

Clinical oral implants research·2026
Same author

Consensus Report of Group 3 of the 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: Advanced Diagnostic Imaging, Augmentation Techniques, and Management of Complications.

Clinical oral implants research·2026

Related Experiment Video

Updated: Apr 21, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.6K

Optimized cell survival and seeding efficiency for craniofacial tissue engineering using clinical stem cell therapy.

Archana Rajan1, Emily Eubanks1, Sean Edwards1

  • 1Department of Orthodontics and Pediatric Dentistry, Department of Periodontics and Oral Medicine, Department of Oral and Maxillofacial Surgery, Center for Oral Health Research, and Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Stem Cells Translational Medicine
|November 8, 2014
PubMed
Summary

Cell therapy successfully regenerated 80% of jawbone lost to traumatic injury, enabling dental implant placement. This innovative approach offers a new solution for craniofacial reconstruction and tooth replacement after severe facial trauma.

Keywords:
Bone marrowBone regenerationCell therapyImplantsScaffoldStem cells

More Related Videos

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

8.9K
Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
11:24

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

15.3K

Related Experiment Videos

Last Updated: Apr 21, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

16.6K
Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

8.9K
Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
11:24

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

15.3K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Oral and Maxillofacial Surgery

Background:

  • Traumatic facial injuries frequently cause craniofacial deficiencies, including jawbone loss and missing teeth.
  • Inadequate jawbone support compromises dental implant success for tooth replacement.
  • Current treatments for severe craniofacial bone defects remain challenging.

Purpose of the Study:

  • To report the successful upper jaw reconstruction using cell therapy in a patient with significant jawbone loss due to traumatic injury.
  • To evaluate the efficacy of autologous stem and progenitor cells seeded onto a beta-tricalcium phosphate (β-TCP) scaffold for bone regeneration.
  • To establish an evidence-based protocol for cell transplantation in craniofacial reconstruction.

Main Methods:

  • A mixed population of bone marrow-derived autologous stem and progenitor cells was seeded onto a β-TCP scaffold.
  • Optimization of cell-scaffold incubation conditions (temperature, time) for maximal cell survival and seeding efficiency.
  • Clinical, radiographic (cone beam computed tomography), and histological analyses were performed post-therapy.
  • Oral implants were placed to support an engineered dental prosthesis.

Main Results:

  • Optimized incubation (30 minutes at any temperature, or 1 hour at 4°C) yielded high cell seeding efficiency (>81%) and survival (94%).
  • Cell therapy regenerated 80% of the jawbone deficiency within 4 months, creating vascularized, mineralized bone.
  • The regenerated bone was sufficient for stable oral implant placement.
  • Functional and aesthetic rehabilitation was achieved with a dental prosthesis 6 months after implant placement.

Conclusions:

  • Cell therapy using autologous stem cells on a β-TCP scaffold is a viable and effective method for reconstructing significant jawbone defects following craniofacial trauma.
  • This approach successfully restored bone volume and quality to support dental implants, enabling functional and aesthetic rehabilitation.
  • This study presents the first clinical report of cell therapy for craniofacial trauma reconstruction, demonstrating a promising new treatment paradigm.