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Intravenous immunoglobulin in pediatrics: A review
A N Prasad1, Sanjay Chaudhary1
1Classified Specialist (Pediatrics), Command Hospital (Western Command), Chandimandir, Panchkula 134107, Haryana, India.
Medical Journal, Armed Forces India
|November 8, 2014
Summary
Intravenous immunoglobulin (IVIG) use is expanding for various conditions in children. This commentary offers evidence-based guidelines for its appropriate application in pediatric immune disorders.
Area of Science:
- Pediatric Immunology
- Immunotherapy
- Clinical Guidelines
Background:
- Intravenous immunoglobulin (IVIG) use has significantly increased for numerous conditions.
- IVIG is administered at replacement doses for antibody deficiencies and high doses for immune/inflammatory disorders.
- Limitations include high cost and the need for intravenous infusions, prompting guideline development.
Purpose of the Study:
- To provide evidence-based recommendations for IVIG use in pediatric and neonatal immune disorders.
- To address the growing use, cost, and shortages of IVIG.
- To offer guidance on appropriate IVIG application in various pediatric conditions.
Main Methods:
- Review of recent publications and existing literature on IVIG use in children.
- Development of evidence-based recommendations.
- Commentary on current practices and guidelines.
Main Results:
- The commentary outlines recommendations for IVIG use in diverse pediatric conditions.
- It addresses both replacement and immunomodulatory applications of IVIG.
- Recent publications supporting these recommendations are cited.
Conclusions:
- Evidence-based guidelines are crucial for the appropriate use of IVIG in children.
- Recommendations aim to optimize IVIG therapy considering its limitations.
- This work supports informed decision-making in pediatric immunotherapy.
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