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Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge
E A Emini1, W A Schleif, M Silberklang
1Department of Virus, Merck, Sharp and Dohme Research Laboratories West Point, Pennsylvania.
Journal of Medical Virology
|February 1, 1989
Abstract:
The Epstein-Barr virus (EBV) major membrane antigen, gp350/220, was purified from expressing, genetically engineered Vero cells. The antigen, formulated either with alum or Freund's adjuvant, was inoculated into EBV infection-susceptible marmosets. After several injections, most of the marmosets developed anti-gp350/220 antibodies, and several exhibited virus-neutralizing activity. The immune response elicited by the alum-absorbed antigen proved to be protective upon virus challenge of the inoculated animals. Protection did not correlate with the presence of neutralizing antibodies.