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Area of Science:

  • Pulmonology
  • Immunology

Background:

  • Bronchiectasis is a common respiratory condition with diverse causes.
  • Common variable immunodeficiency disorder (CVID) is an infrequent but significant cause of bronchiectasis.
  • Bronchiectasis in CVID patients is often underdiagnosed due to a lack of suspicion for primary immunodeficiency in adults.

Purpose of the Study:

  • To highlight the association between bronchiectasis and CVID.
  • To emphasize the importance of considering CVID in adults presenting with bronchiectasis and multisystem symptoms.
  • To underscore the diagnostic challenges and the need for routine immunoglobulin level measurement.

Main Methods:

  • Case report of a young man with bronchiectasis and multisystem complaints.
  • Diagnostic workup including assessment for primary immunodeficiency.

Main Results:

  • The patient presented with bronchiectasis and various extrapulmonary symptoms.
  • Diagnosis of Common Variable Immunodeficiency Disorder (CVID) was established.

Conclusions:

  • CVID should be considered in the differential diagnosis of bronchiectasis, especially in adults with unexplained respiratory symptoms and extrapulmonary manifestations.
  • Prompt diagnosis of CVID can lead to timely management and potentially improve patient outcomes.
  • Measuring serum immunoglobulin levels is crucial for identifying CVID in patients with recurrent respiratory infections and bronchiectasis.