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Ramucirumab: preclinical research and clinical development
Giuseppe Aprile1, Erika Rijavec2, Caterina Fontanella1
1Department of Oncology, University Hospital of Udine, Udine, Italy.
Oncotargets and Therapy
|November 8, 2014
Summary
Ramucirumab, a VEGFR-2 inhibitor, shows promise in treating advanced gastric cancer. Its efficacy in other cancers like lung and breast cancer requires further investigation.
Area of Science:
- Oncology
- Immunotherapy
- Molecular Biology
Background:
- Ramucirumab is a fully humanized monoclonal antibody targeting vascular endothelial growth factor receptor 2 (VEGFR-2).
- It selectively inhibits VEGFR-2 with high affinity, impacting angiogenesis.
Purpose of the Study:
- To review preclinical and clinical studies on ramucirumab development.
- To present randomized clinical trial results for ramucirumab in various cancers.
Main Methods:
- Review of preclinical data and early clinical studies.
- Analysis of randomized clinical trials evaluating ramucirumab efficacy.
Main Results:
- Ramucirumab received FDA approval for advanced gastric and gastroesophageal junction carcinoma.
- Its role in metastatic breast cancer and non-small-cell lung cancer remains under investigation.
Conclusions:
- Ramucirumab is an emerging therapeutic option for specific advanced cancers.
- Further research is needed to define its role in other malignancies.
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