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Testosterone, HDL and cardiovascular risk in men: the jury is still out

Katya B Rubinow1, Stephanie T Page2

  • 1Center for Research in Reproduction & Contraception, University of Washington School of Medicine, Seattle, WA, USA and Diabetes & Obesity Center of Excellence, Division of Metabolism, Endocrinology & Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Clinical Lipidology
|November 8, 2014
PubMed

Insights

Androgen therapy can lower HDL-cholesterol levels. However, the impact of these changes on cardiovascular risk is not yet clear.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Androgen therapy is used for various conditions.
  • Changes in lipid profiles, including high-density lipoprotein (HDL)-cholesterol, are noted with androgen use.

Purpose of the Study:

  • To evaluate the cardiovascular risk implications of androgen therapy-induced HDL-cholesterol reductions.

Main Methods:

  • Observational studies analyzing lipid profiles and cardiovascular events in patients undergoing androgen therapy.
  • Statistical analysis to correlate changes in HDL-cholesterol with cardiovascular risk markers.

Main Results:

  • Reductions in HDL-cholesterol were observed in some patients receiving androgen therapy.
  • The clinical significance of these HDL-cholesterol changes for cardiovascular risk remains uncertain.

Conclusions:

  • The observed decrease in HDL-cholesterol during androgen therapy does not have clear implications for cardiovascular risk.
  • Further research is needed to understand the relationship between androgen therapy, HDL-cholesterol, and cardiovascular outcomes.

Keywords:
HDLandrogenscardiovascular diseasecholesteroltestosterone

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