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Acute nutritional ketosis: implications for exercise performance and metabolism
1Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK ; Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Extreme Physiology & Medicine
|November 8, 2014
Summary
Ketone bodies like acetoacetate (AcAc) and D-β-hydroxybutyrate (βHB) can fuel exercise as an alternative carbon source. Harnessing ketosis may influence athletic performance and offer therapeutic applications.
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Metabolic Science
Background:
- Ketone bodies (acetoacetate and D-β-hydroxybutyrate) are evolutionary adaptations for survival during caloric deprivation.
- These compounds offer an alternative energy substrate beyond carbohydrates and fats.
Purpose of the Study:
- To examine the energetic implications of ketone body utilization during exercise.
- To explore the application of ketosis in athletic performance and therapeutic contexts.
Main Methods:
- Review of metabolic actions and energetic contributions of ketone bodies.
- Analysis of substrate energetics in the context of exercise metabolism.
Main Results:
- Ketone bodies can serve as an alternative fuel source for exercise.
- Their metabolic actions have potential implications for athletic performance.
Conclusions:
- Ketone body supplementation may influence exercise metabolism.
- Understanding ketosis offers insights for both sports nutrition and clinical applications.
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