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Cortical substrates and functional correlates of auditory deviance processing deficits in schizophrenia
Anthony J Rissling1, Makoto Miyakoshi2, Catherine A Sugar3
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Neuroimage. Clinical
|November 8, 2014
Summary
Schizophrenia patients show altered auditory deviance responses (ADR). Source-resolved ADR measures, particularly mismatch negativity (MMN), reveal significant links to cognitive and symptom severity in schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Sensory processing abnormalities are linked to cognitive and psychosocial deficits in schizophrenia.
- Standard scalp-channel electroencephalography (EEG) measures of event-related potentials (ERPs) can dilute the functional relevance of distinct cortical source contributions.
Purpose of the Study:
- To identify the cortical sources of the auditory deviance response (ADR) in schizophrenia patients.
- To investigate the relationship between source-resolved ADR contributions and clinical, cognitive, and psychosocial measures in schizophrenia.
Main Methods:
- Utilized independent component analysis (ICA) on 68-channel EEG data from schizophrenia patients (n=42) and controls (n=47) during an auditory oddball paradigm.
- Clustered independent components (ICs) based on spectral, ERP, and topographic similarities to identify distinct neural sources.
- Correlated source-resolved ADR measures with clinical, cognitive, and psychosocial functioning assessments.
Main Results:
- Six IC clusters with triphasic ADR contributions were identified, localized to specific cortical regions including the right superior temporal and medial orbitofrontal cortex.
- Source-resolved ADR measures showed significant correlations with clinical and functional outcomes, unlike standard scalp-channel measures.
- Mismatch negativity (MMN) amplitude in the right superior temporal IC cluster explained 48% of the variance in real-world functioning, and P3a amplitude in the medial orbitofrontal cluster explained 40-54% of the variance in positive/negative symptoms.
Conclusions:
- Source-resolved auditory deviance response measures, particularly MMN, are more sensitive to schizophrenia's clinical, cognitive, and functional characteristics than traditional scalp-channel analyses.
- ICA-based source localization offers a more functionally relevant approach to understanding neural processing abnormalities in schizophrenia.
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