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Updated: Apr 21, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Today prospects for tissue engineering therapeutic approach in dentistry
Maurizio Bossù1, Andrea Pacifici1, Daniele Carbone1
1Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.
Dental stem cells offer promising regenerative potential for oral tissues lost due to inflammation or trauma. This review explores current knowledge and clinical applications of these valuable adult mesenchymal stem cells.
Area of Science:
- Regenerative Medicine
- Dental Research
- Tissue Engineering
Background:
- Increasing need for predictable tissue regeneration protocols in dentistry.
- Tissue engineering and stem cells are key areas of interest in regenerative medicine.
- Significant growth in literature concerning stem cells in dentistry.
Purpose of the Study:
- To provide an overview of current knowledge on dental stem cells.
- To identify potential clinical applications of dental stem cells.
- To explore the use of adult mesenchymal stem cells in oral tissue regeneration.
Main Methods:
- Literature review on dental stem cells.
- Characterization of adult mesenchymal stem cells from tooth-related tissues.
- Analysis of current research on stem cell applications in dentistry.
Main Results:
- Adult mesenchymal stem cells have been isolated and characterized from dental tissues.
- Dental stem cells show potential as a gold standard for oral tissue regeneration.
- Various classes of dental stem cells have demonstrated therapeutic potential.
Conclusions:
- Dental stem cells represent a significant advancement in regenerative dentistry.
- Future clinical applications are anticipated across multiple dental specialties.
- Further research into dental stem cell therapies is warranted for oral tissue repair.
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