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Published on: August 13, 2013
Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells
R E Scott1, D N Estervig, C Y Tzen
1Section of Experimental Pathology, Mayo Clinic/Foundation, Rochester, MN 55905.
Abstract:
The potential of nonterminal cellular differentiation to stably repress the expression of the neoplastic phenotype of transformed cells is established. Nonterminal differentiation induces spontaneously transformed 3T3 T cells to revert to a nontransformed state and induces the revertant cell clones to become resistant to retransformation by UV irradiation or 4-nitroquinoline oxide treatment. Nonterminal differentiation also induces simian virus 40-transformed 3T3 T cells to repress expression of the large tumor antigen and to revert to a nontransformed state. Although the molecular mechanisms that mediate these and other forms of anticancer activity have not been definitively established, data are presented which suggest that differentiation-induced repression of large tumor antigen expression can be regulated at the level of transcription and/or RNA processing.
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