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Updated: Apr 21, 2026
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Stimulation of the efferent limb before ileostomy closure: a randomized clinical trial
J Abrisqueta1, I Abellan, J Luján
1Department of General Surgery, Colorectal Unit, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain.
Background:
Postoperative ileus is the most common complication after ileostomy closure with an increase in morbidity, hospital stay, and health care costs.
Objective:
The aim of this study is to assess the utility of a new technique for reducing postoperative ileus after protective ileostomy closure.
Design:
This is a prospective randomized study registered at ClinicalTrials.gov (NCT01881594). Patients were randomly assigned to undergo either stimulation through the efferent limb of the ileostomy before surgery or nonstimulation before surgery.
Setting:
This study was conducted at the Department of Surgery of the Virgen de la Arrixaca Clinical University Hospital (Murcia).
Patients:
Seventy patients underwent surgery for ileostomy closure. In 35 patients, during the 2 weeks before surgery, daily stimulation of the defunctionalized stomal segment was performed by using a thick solution (500 mL of physiological saline associated with 30 g of thickening agent, Nestle Resource, Vevey, Switzerland). In the other 35 patients, stimulation was not performed before surgery.
Main Outcome Measures:
The primary outcome was postoperative ileus. The secondary outcomes included time to tolerating a diet and postoperative stay.
Results:
Both groups of patients were homogenous for demographic data, characteristics of the first rectal cancer operation, and intersurgery periods. After ileostomy closure, the stimulated group of patients had an earlier return to oral tolerance (1.06 vs 2.57 days; p = 0.007) and passage of flatus or stool (1.14 vs 2.85 days; p <0.001) than the nonstimulated group of patients. The incidence of postoperative ileus (2.85% vs 20%; p = 0.024) and hospital stay (2.49 vs 4.61 days; p = 0.002) was also lower in the stimulated patients.
Limitations:
Small numbers of patients means that no definitive statements can be made regarding the effectiveness of this technique.
Conclusions:
Stimulation of the efferent limb of the ileostomy before closure is a safe technique that reduces postoperative ileus and fosters early intestinal transit and oral tolerance with a shorter postoperative hospital stay.
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