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The bovine papillomavirus type 1 transcriptional activator E2 protein binds to its DNA recognition sequence as a
1Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710.
Virology
|March 1, 1989
Abstract:
The transcriptional trans-activator E2 protein from bovine papillomavirus type 1 has been shown to bind to the DNA consensus sequence ACCN6GGT. We have produced the DNA-binding domain of the E2 protein as a recombinant protein in Escherichia coli. The E2 DNA-binding domain was purified as two different molecular weight forms. Using these purified proteins, we show that two molecules of the E2 protein bind to a single DNA consensus binding site.