Related Experiment Video
Updated: Apr 21, 2026
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Initial experience with endoscopic sleeve gastroplasty: technical success and reproducibility in the bariatric
Reem Z Sharaiha1, Prashant Kedia1, Nikhil Kumta1
1Division of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medical College, New York, USA.
Background And Aims:
Novel endoscopic techniques have been developed as effective treatments for obesity. Recently, reduction of gastric volume via endoscopic placement of full-thickness sutures, termed endoscopic sleeve gastroplasty (ESG), has been described. Our aim was to evaluate the safety, technical feasibility, and clinical outcomes for ESG.
Patient And Methods:
Between August 2013 and May 2014, ESG was performed on 10 patients using an endoscopic suturing device. Their weight loss, waist circumference, and clinical outcomes were assessed.
Results:
Mean patient age was 43.7 years and mean body mass index (BMI) was 45.2 kg/m(2). There were no significant adverse events noted. After 1 month, 3 months, and 6 months, excess weight loss of 18 %, 26 %, and 30 %, and mean weight loss of 11.5 kg, 19.4 kg, and 33.0 kg, respectively, were observed. The differences observed in mean BMI and waist circumference were 4.9 kg/m(2) (P = 0.0004) and 21.7 cm (P = 0.003), respectively.
Conclusions:
ESG is effective in achieving weight loss with minimal adverse events. This approach may provide a cost-effective outpatient procedure to add to the steadily growing armamentarium available for treatment of this significant epidemic.
