Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels
Torbjörn Åkerfeldt1, Lena Gunningberg2, Christine Leo Swenne3
1Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. torbjorn.akerfeldt@akademiska.se.
Background:
Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.
Methods:
Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.
Results:
Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.
Conclusion:
Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
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