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A Protocol for Computer-Based Protein Structure and Function Prediction

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Published on: November 3, 2011

PolyprOnline: polyproline helix II and secondary structure assignment database.

Romain Chebrek¹, Sylvain Leonard², Alexandre G de Brevern²

¹Inserm U1134, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France, Institut National de la Transfusion Sanguine, Paris, France and Laboratory of Excellence GR-Ex, Paris, France Inserm U1134, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France, Institut National de la Transfusion Sanguine, Paris, France and Laboratory of Excellence GR-Ex, Paris, France Inserm U1134, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France, Institut National de la Transfusion Sanguine, Paris, France and Laboratory of Excellence GR-Ex, Paris, France.

Database : the Journal of Biological Databases and Curation

|November 9, 2014

Summary

This summary is machine-generated.

The polyproline helix type II (PPII) is a crucial protein structure, often overlooked by current tools. The PolyprOnline database now aids in its study and analysis.

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Area of Science:

Structural biology
Bioinformatics

Background:

Polyproline helix type II (PPII) is a significant protein secondary structure.
PPII plays vital roles in biological macromolecule interactions.
PPII constitutes 3-10% of protein residues but is understudied.

Purpose of the Study:

To introduce the PolyprOnline database for PPII structure assignment and analysis.
To facilitate research on the structure and function of PPII.

Main Methods:

Development of a dedicated database for PPII analysis.
Assignment and analysis of PPII structures.

Main Results:

Most popular assignment tools do not identify PPII structures.
The PolyprOnline database provides a dedicated resource for PPII study.

Conclusions:

The PolyprOnline database addresses the gap in PPII structure analysis.
This resource will aid in understanding the functional roles of PPII.