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Neurological development of children born to liver transplant recipients

J Schreiber-Zamora1, B Kociszewska-Najman1, B Borek-Dzięcioł1

  • 1Division of Neonatology, 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.

Transplantation Proceedings
|November 9, 2014
PubMed

Insights

Children born to mothers who received liver transplants show normal neurological development, similar to those in a control group. This indicates immunosuppressive treatment during pregnancy does not negatively impact child neurodevelopment.

Area of Science:

  • Pediatric Neurology
  • Transplant Medicine
  • Obstetrics

Background:

  • Immunosuppressive therapy in pregnant liver transplant recipients (LTRs) raises concerns about potential adverse effects on fetal development.
  • Assessing the long-term neurological outcomes in children born to LTRs is crucial for understanding the safety of such treatments during pregnancy.

Purpose of the Study:

  • To conduct a neurological assessment of infants and children born to liver transplant recipients.
  • To compare the neurological development of children born to LTRs with a control group of children born to non-recipients.

Main Methods:

  • A cohort of 88 children was studied: 44 born to LTR mothers and 44 to non-recipients, matched for gestational age.
  • Neurological examinations were performed on children aged 7 weeks to 10 years by a pediatric neurologist.
  • Statistical analysis utilized the Fisher's exact test to compare developmental outcomes.

Main Results:

  • Normal neurological development was observed in 79.54% of children in the LTR group and 88.63% in the control group (P = .3827).
  • Slight neurological disorders were present in 13.63% of the LTR group and 11.36% of the control group.
  • Moderate disorders were found in 6.81% of the LTR group; no severe disorders were noted in either group.

Conclusions:

  • Neurological development in children born to mothers who underwent liver transplantation is comparable to that of children from mothers without organ transplants.
  • Chronic immunosuppressive treatment during fetal life does not appear to adversely affect the neurological development of offspring.
Abstract

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