Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

5.9K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.9K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

7.0K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
7.0K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

588
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
588

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CFTR modulators: a new class of antimicrobials in lung infection?

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Condensation of cGAS induced by Tyr<sup>242</sup> phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.

Science signaling·2026
Same author

A precision approach to translational research in acute lung injury.

American journal of respiratory and critical care medicine·2026
Same author

Intravascular hemolysis aggravates ventilator-induced lung injury in mice.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Call for Papers: Cystic fibrosis and other lung diseases in the CFTR modulator era.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Multiomics approaches to cardiovascular disease: technological innovations and clinical translation.

American journal of physiology. Heart and circulatory physiology·2026

Related Experiment Video

Updated: Apr 21, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K

Novel regulators of endothelial barrier function.

Dolly Mehta1, Krishnan Ravindran2, Wolfgang M Kuebler

  • 1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois; dmehta@uic.edu.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|November 9, 2014
PubMed
Summary

Maintaining endothelial barrier integrity is crucial for preventing fatal vascular leakage in conditions like sepsis. This review explores recent advances in understanding endothelial permeability regulation, focusing on key cellular components and signaling pathways.

Keywords:
acute lung injury/acute respiratory distress syndromeedemaendothelial cellpermeability

More Related Videos

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors
09:38

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

1.2K
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

17.6K

Related Experiment Videos

Last Updated: Apr 21, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K
Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors
09:38

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

1.2K
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

17.6K

Area of Science:

  • Vascular Biology
  • Cellular Physiology
  • Immunology

Background:

  • Endothelial barrier function is vital for vascular and interstitial space compartmentalization.
  • Failure to maintain endothelial integrity leads to fatal fluid and protein leakage, seen in sepsis and ARDS.
  • Understanding endothelial permeability is critical for treating critical illnesses.

Purpose of the Study:

  • To review recent advances in endothelial permeability regulation.
  • To focus on the roles of the endothelial glycocalyx and scaffolds.
  • To discuss regulatory signaling, triggers, and mediators of endothelial barrier integrity.

Main Methods:

  • Literature review of recent advances in endothelial barrier research.
  • Focus on specific molecular and cellular mechanisms.
  • Identification of controversies and knowledge gaps.

Main Results:

  • Recent advances have elucidated the roles of the endothelial glycocalyx and scaffolds.
  • Intracellular signaling cascades are key regulators of endothelial permeability.
  • Various mediators and triggers differentially impact barrier integrity.

Conclusions:

  • Continued research into endothelial barrier regulation is essential.
  • Addressing knowledge gaps and controversies will advance therapeutic strategies.
  • Improved understanding may lead to novel treatments for vascular leakage disorders.