Related Experiment Video
Updated: Apr 21, 2026
12:14
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
36.5K
Ischemic stroke associated with immune thrombocytopenia
HongMei Zhao1, YaJun Lian, HaiFeng Zhang
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China.
Journal of Thrombosis and Thrombolysis
|November 9, 2014
Summary
This review examines rare cases of ischemic stroke and immune thrombocytopenia (ITP) co-occurring in patients. Further research is needed to understand the paradoxical mechanisms and optimal management strategies for this syndrome.
Area of Science:
- Neurology
- Hematology
- Internal Medicine
Background:
- Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts.
- Ischemic stroke involves a blockage of blood supply to the brain.
- The co-occurrence of ITP and ischemic stroke is exceptionally rare.
Observation:
- A literature review identified 18 cases of patients with both ischemic stroke and ITP.
- An additional case was analyzed, bringing the total to 19 patients.
- Patients presented with varied clinical manifestations and ischemic lesion patterns.
- Most patients had low platelet counts, and brain imaging (CT/MRI) was performed in all cases.
Findings:
- The study analyzed clinical features and ischemic patterns in 19 patients.
- Demographic data revealed a mix of ages and nationalities, with a notable number of younger patients (<50 years).
- The prognosis for ischemic stroke was generally good in 18 out of 19 patients.
Implications:
- The simultaneous presentation of ischemic stroke and ITP is a rare clinical syndrome.
- Understanding the paradoxical mechanisms underlying this association is crucial.
- Further investigation is required to establish effective management protocols for patients with concurrent ischemic stroke and ITP.
Related Concept Videos
01:15Ischemic Stroke l: Introduction
7
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
7
01:26Transient Ischemic Attack l: Introduction
2
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
2
01:15Ischemic Stroke ll: Pathophysiology
5
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
5
01:29Hemorrhagic Stroke ll: Pathophysiology
6
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
6
01:19Encephalitis l: Introduction
5
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
5
01:26Encephalitis ll: Pathophysiology
9
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
9