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Alternative splicing of human insulin receptor messenger RNA
1Howard Hughes Medical Institute, Department of Biochemistry, University of Chicago, IL 60637.
Biochemical and Biophysical Research Communications
|February 28, 1989
Abstract:
The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding alpha-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.