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The roles of Egr-2 in autoimmune diseases

Min Zhang1, Ying Wang, Jian-Shu Wang

  • 1Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.

Inflammation
|November 10, 2014
PubMed

Being a member of the early growth response (Egr) family of transcription factors, Egr-2 is expressed in a variety of cell types of the immune system. Recent findings imply that Egr-2 is important in the development and function of T helper (Th) 17 cell, regulatory T (Treg) cell, as well as dendritic cell (DC). Although these cells perform significantly in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and systemic sclerosis, the roles of Egr-2 in the pathogenesis of autoimmune diseases can not be neglected. In this article, we will discuss recent findings about the important roles of Egr-2 in immune cells and the possible pathological roles of Egr-2 in autoimmune diseases.

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