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Updated: Apr 21, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Clinical implications of basic science discoveries: janus resurrected--two faces of B cell and plasma cell biology

E S Woodle1, D M Rothstein

  • 1Division of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|November 11, 2014
PubMed

B cells play a complex role in the immune response. In addition to giving rise to plasma cells (PCs) and promoting T cell responses via antigen presentation, they perform immunoregulatory functions. This knowledge has created concerns regarding nonspecific B cell depletional therapy because of the potential to paradoxically augment immune responses. Recent studies now indicate that PCs have immune functions beyond immunoglobulin synthesis. Evidence for a new role for PCs as potent regulatory cells (via IL-10 and IL-35 production) is discussed including the implications for PC-targeted therapies currently being developed for clinical transplantation.

Keywords:
B cell biologycellular biologyeditorial/personal viewpointimmune regulationimmunobiologyimmunosuppression/immune modualtionlymphocyte biologyplasma cells

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