Related Experiment Video

Updated: Apr 21, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.5K

Virus profile in children with acute respiratory infections with various severities in Beijing, China

Runan Zhu1, Qinwei Song1, Yuan Qian1

  • 1Laboratory of Virology, Capital Institute of Pediatrics, Beijing 100020, China.

Chinese Medical Journal
|November 11, 2014
PubMed

Insights

This study identified common and uncommon respiratory viruses in children with acute respiratory infections (ARI). Findings show higher viral detection rates and co-infections in hospitalized children, emphasizing broader testing for severe cases.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health

Background:

  • Acute respiratory infection (ARI) is a significant global health concern in infants and young children.
  • Understanding the viral etiology of ARI is crucial for effective management and prevention strategies.

Purpose of the Study:

  • To determine the virus profile in children with ARI across different severity levels.
  • To compare viral detection rates and distributions between outpatient, inpatient, and intensive care unit (ICU) patient groups.

Main Methods:

  • Clinical specimens from 270 children with ARI in Beijing were analyzed.
  • An xTAG Respiratory Viral Panel Fast (RVP Fast) assay was used to detect 18 respiratory viruses.
  • Pearson chi-square analysis was employed for statistical significance.

Main Results:

  • Viruses were detected in 65.2% of ARI cases.
  • Viral detection rates were significantly higher in inpatients (71.1%) and ICU patients (74.4%) compared to outpatients (50.0%).
  • Human rhinovirus (HRV), respiratory syncytial virus (RSV), and adenovirus (ADV) were frequently detected, particularly in severe cases. Co-infection rates varied by severity.

Conclusions:

  • The study highlights the importance of testing for both common and less common respiratory viruses in children with ARI.
  • Broader viral diagnostic panels are recommended for children presenting with severe ARI-related clinical illnesses.
Abstract

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

3.0K
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.8K

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
6.4K
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
165
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
62
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.7K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1.7K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
695