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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
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Intrathecal Pump: An Abrupt Intermittent Pump Failure.

John Riordan1, Paul Murphy1

  • 1Department of Anaesthesia, Intensive Care and Pain Medicine, St. Vincent's University Hospital, Dublin, Ireland.

Neuromodulation : Journal of the International Neuromodulation Society
|November 11, 2014
PubMed
Summary

Intrathecal baclofen pump failure due to motor stall and corrosion can cause spasticity symptom recurrence. Prompt pump replacement and vigilance are crucial for managing intrathecal baclofen therapy complications.

Keywords:
Baclofencase reportintrathecal drug deliverysafetywithdrawal

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Area of Science:

  • Neurology
  • Biomedical Engineering

Background:

  • Intrathecal baclofen (ITB) therapy is a common treatment for severe spasticity.
  • However, ITB pump systems are associated with significant risks, including device malfunction and patient morbidity.

Observation:

  • A patient with a Medtronic SynchroMed II intrathecal pump experienced recurrent motor stalls, leading to worsening spasticity and pain.
  • Device interrogation confirmed motor stall, and the patient reported intermittent alarming for three days prior to urgent review.

Findings:

  • Internal inspection of the explanted SynchroMed II pump revealed motor gearbox corrosion as the cause of failure.
  • Replacement of the intrathecal pump restored the patient's usual symptom relief, indicating successful intervention.

Implications:

  • This case highlights the importance of vigilance for potential complications, such as motor stall and corrosion, in ITB pump therapy.
  • Supplemental oral baclofen may serve as a temporary measure during pump malfunction or replacement.
  • Further investigation into the long-term reliability and failure modes of ITB pump systems is warranted.