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Multifunctional "smart" particles engineered from live immunocytes: toward capture and release of cancer cells

Chao Huang¹, Gao Yang, Qing Ha

¹Laboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.

Advanced Materials (Deerfield Beach, Fla.)

|November 11, 2014

Abstract:

Multifunctional "smart" particles with magnetic, topographic, cell-targeting, and stimulus-responsive properties are obtained using a "live template" strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enable the release of captured cells with high viability via reduction of disulfide bonds. Diverse multifunctional particles can be designed using the "live template" strategy.

Keywords:

cell capture cell release topographic structures “live template”“smart” particles

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