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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
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Demineralized bone matrix for alveolar cleft management
Jose Rolando Prada Madrid1, Viviana Gomez2, Bibiana Mendoza3
1Department of Plastic and Reconstructive Surgery, Hospital Intantil Universitario San Jose and FISULAB, Bogotá, Colombia.
Craniomaxillofacial Trauma & Reconstruction
|November 11, 2014
Summary
Demineralized bone matrix putty showed unsatisfactory bone formation in alveolar cleft repair for patients with cleft lip and palate. Further research is needed to improve bone regeneration outcomes in these complex cases.
Area of Science:
- Craniofacial surgery
- Regenerative medicine
- Oral and maxillofacial surgery
Background:
- Alveolar clefts in patients with cleft lip and palate often require bone grafting for successful repair.
- Demineralized bone matrix (DBM) is a biomaterial used in bone regeneration, but its efficacy in alveolar cleft reconstruction needs further evaluation.
Purpose of the Study:
- To evaluate the clinical outcomes of using demineralized bone matrix putty for alveolar cleft reconstruction.
- To assess bone formation and graft integration using cone beam computed tomography (CBCT).
Main Methods:
- Prospective, descriptive case series study involving 10 patients (13 clefts) aged 7–26 years.
- Preoperative CBCT to measure cleft width (average 11.18 mm).
- Postoperative CBCT at 6 months to assess bone density (average gray value 1,270).
Main Results:
- Follow-up ranged from 15 to 33 months (average 28.2 months).
- CBCT analysis indicated insufficient bone formation in the alveolar clefts treated with DBM putty.
- Clinical outcomes were not satisfactory regarding bone regeneration.
Conclusions:
- Demineralized bone matrix putty demonstrated limited efficacy in achieving satisfactory bone formation for alveolar cleft repair.
- Alternative or adjunctive bone grafting materials may be necessary for optimal outcomes in cleft lip and palate patients.
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